Certain statins are associated with a higher incidence of myopathy. Bruckert et al used pravastatin as a reference and demonstrated that atorvastatin and simvastatin were associated with higher incidences of myopathy, whereas fluvastatin XL was associated with a lower incidence.

Which statin causes the most myopathy?

Certain statins are associated with a higher incidence of myopathy. Bruckert et al used pravastatin as a reference and demonstrated that atorvastatin and simvastatin were associated with higher incidences of myopathy, whereas fluvastatin XL was associated with a lower incidence.

Which statin does not interact with cyclosporine?

The use of lovastatin, pitavastatin, and simvastatin should be avoided in patients receiving cyclosporine, tacrolimus, everolimus, or sirolimus as consistent with product labeling.

Which statin can be used with cyclosporine?

The safest statin for posttransplant patients and others on long-term cyclosporin therapy is fluvastatin. Pravastatin has no significant cytochrome P450 drug interactions.

Can myopathy caused by statins be reversed?

While myopathy caused by statins can be mild and can be reversed when the medication is discontinued, it may present as rhabdomyolysis or severe muscle damage.

Which statin has the lowest risk of myopathy?

Considering the results of the PRIMO study, the use of statins associated with a lower risk of myopathy, such as fluvastatin or pravastatin, may be considered (4), although these statins may not be potent enough if a large reduction of LDL cholesterol is needed to reach target values.

Which statin has least risk for myopathy?

That being said, an approximation of potential for causing myopathy among the currently available statins, based on various pharmacological attributes is, from least likely to be associated with myopathy to most likely: pravastatin, fluvastatin, rosuvastatin, atorvastatin, lovastatin and simvastatin.

Can I take atorvastatin with cyclosporine?

cycloSPORINE atorvastatin Combining these medications may significantly increase the blood levels of atorvastatin. This can increase the risk of side effects such as liver damage and a rare but serious condition called rhabdomyolysis that involves the breakdown of skeletal muscle tissue.

Does atorvastatin interact with cyclosporine?

Conclusions: Atorvastatin coadministration increases the cyclosporine AUC by approximately 10% in stable liver transplant recipients. This change in systemic exposure to cyclosporine is of questionable clinical significance. Atorvastatin is effective in reducing cholesterol levels in liver transplant recipients.

What does statin myopathy feel like?

Statin-related muscle pain, if it happens at all, usually happens within the first few months after you start the drug or raise the dose. You may feel a constant soreness or weakness in your shoulders, thighs, hips, or calves. If you’re like most people, it’ll affect both sides of your body equally.

How long does it take to recover from statin myopathy?

In 44 patients, medical records indicated recovery from statin-associated myopathy a mean of 2.3 (3.0) months after the cessation of statin therapy (range, 0.25-14.0 months) (Table 4).

How long does it take to recover from statin induced myopathy?

Is muscle damage from statins reversible?

Specifically, statins may lead to muscle damage in 1 in 10,000 people who take this type of drug each year. The damage is typically reversible once the person stops taking the statin.

Does ciclosporin interact with statins?

PHARMAC data indicates that approximately one third of patients taking ciclosporin are also taking a statin. Pharmacokinetic studies confirm that ciclosporin interacts with all statins to increase the plasma levels of the statin 3,4.

Can cyclosporine cause creatine kinase to increase?

Increased dosage of cyclosporine induces myopathy with increased seru creatine kinase in an elderly patient on chronic statin therapy Cyclosporine is a moderate inhibitor of the cytochrome P450 CYP3A4 isoenzyme, which is known to increase the serum level of atorvastatin.

Can statins cause autoimmune myopathy?

Keywords: statin-induced necrotizing autoimmune myopathy, statin-associated autoimmune myopathy, immune-mediated necrotizing myopathy Introduction Myalgia related to statin administration is generally a self-limited side effect.

Is ciclosporin a CYP3A4 inhibitor?

Ciclosporin is an inhibitor of CYP3A4 as well as several membrane transporters, including OATP2 and P-glycoprotein 5. The metabolic pathways of statins include CYP3A4, OATP2 and P-glycoprotein (Table 1).