Lapatinib is used with capecitabine (Xeloda) to treat a certain type of advanced breast cancer in people who have already been treated with other chemotherapy medications.

What is lapatinib used to treat?

Lapatinib is used with capecitabine (Xeloda) to treat a certain type of advanced breast cancer in people who have already been treated with other chemotherapy medications.

How do you take lapatinib?

Take lapitinib exactly as instructed by your doctor. Lapitinib should be taken at least one hour before, or at least one hour after food (take total dose at the same time daily, dividing doses is not recommended). Do not eat or drink grapefruit products while taking lapatinib.

Is capecitabine a chemotherapy?

Capecitabine is a type of chemotherapy. It is used as a treatment for different types of cancer, including bowel cancer. You might have capecitabine on its own or with other chemotherapy drugs. You might also have it with radiotherapy.

What are side effects of capecitabine?

Nausea, vomiting, loss of appetite, constipation, tiredness, weakness, headache, dizziness, trouble sleeping, or changes in taste may occur. Nausea and vomiting can be severe. In some cases, your doctor may prescribe medication to prevent or relieve nausea and vomiting.

Who makes lapatinib?

Pharmaceutical company GlaxoSmithKline (GSK) markets the drug under the propriety names Tykerb (mostly U.S.) and Tyverb (mostly Europe and Russia).

How is lapatinib ditosylate monohydrate (lapatinib) administered?

Available as lapatinib ditosylate monohydrate; dosage expressed in terms of lapatinib. Lapatinib/letrozole: Lapatinib 1.5 g once daily, given continuously in combination with letrozole 2.5 mg once daily. In clinical trial evaluating this regimen, treatment was continued until disease progression occurred or patient withdrew from study.

What is lapatinib (lapatinib)?

MECHANISM OF ACTION: Lapatinib is an orally active small molecule tyrosine kinase inhibitor. It is a potent, reversible, and selective inhibitor of both EGFR and HER2 receptors, and induces growth arrest or apoptosis in EGFR-dependent or HER2-dependent tumour cell lines. 1,4

How is lapatinib (capecitabine) administered?

Lapatinib/capecitabine: When used concomitantly with a potent CYP3A4 inhibitor, manufacturer recommends lapatinib 500 mg once daily. When used concomitantly with a potent CYP3A4 inducer, manufacturer recommends gradually titrating lapatinib dosage from 1.25 g once daily up to 4.5 g once daily, based on tolerability.

How much letrozole can you take with lapatinib?

Lapatinib/letrozole: When used concomitantly with a potent CYP3A4 inhibitor, manufacturer recommends lapatinib 500 mg once daily. When used concomitantly with a potent CYP3A4 inducer, manufacturer recommends gradually titrating lapatinib dosage from 1.5 g once daily up to 5.5 g once daily, based on tolerability.