Edetic acid is a chelating agent used to treat mercury and lead toxicity and some blood transfusion dependent anemias. A chelating agent (chelating agents) that sequesters a variety of polyvalent cations. It is used in pharmaceutical manufacturing and as a food additive.

What is Edetic acid used for?

Edetic acid is a chelating agent used to treat mercury and lead toxicity and some blood transfusion dependent anemias. A chelating agent (chelating agents) that sequesters a variety of polyvalent cations. It is used in pharmaceutical manufacturing and as a food additive.

Is EDTA Edetic acid?

chelating agents, particularly salts of EDTA, or edetic (ethylenediaminetetraacetic) acid, are widely used for direct treatment of metal poisoning because they bind the toxic metal ions more strongly than do the vulnerable components of the living organism.

What is EDTA chemistry?

A chemical that binds certain metal ions, such as calcium, magnesium, lead, and iron. It is used in medicine to prevent blood samples from clotting and to remove calcium and lead from the body. It is also used to keep bacteria from forming a biofilm (thin layer stuck to a surface). It is a type of chelating agent.

How is EDTA created?

It is a polyprotic acid containing four carboxylic acid groups (acidic hydrogens are red) and two amine groups with lone pair electrons (green dots). The classic structural formula is given below. EDTA is synthesized on an industrial scale from ethylenediamine, formaldehyde, and a source of cyanide (HCN or NaCN).

Does EDTA remove plaque from arteries?

Artery plaques contain calcium. The chelating drug disodium EDTA binds to this mineral. The idea is that chelation therapy clears it out of the blood vessels. It removes plaques, too.

Why is EDTA used?

In manufacturing, EDTA is used to improve stability of some pharmaceutical products, detergents, liquid soaps, shampoos, agricultural chemical sprays, contact lens cleaners and cosmetics. It is also used in certain blood collection tubes used by medical laboratories.

What is the difference between EDTA and disodium EDTA?

The key difference between disodium EDTA and tetrasodium EDTA is that disodium EDTA has a pH lower than 7 while tetrasodium EDTA has a pH greater than 7. EDTA is a chelating agent. Therefore, it has the potential to bind with metal ions such as calcium and magnesium. EDTA stands for Ethylenediaminetetraacetic acid.

Why is EDTA used in hardness of water?

Hardness of water is determined by titrating with a standard solution of ethylene diamine tetra acetic acid (EDTA) which is a complexing agent. Since EDTA is insoluble in water, the disodium salt of EDTA is taken for this experiment. EDTA can form four or six coordination bonds with a metal ion.

What are the side effects of EDTA?

EDTA can cause abdominal cramps, nausea, vomiting, diarrhea, headache, low blood pressure, skin problems, and fever. It is UNSAFE to use more than 3 grams of EDTA per day, or to take it longer than 5 to 7 days. Too much can cause kidney damage, dangerously low calcium levels, and death.

Can EDTA cause organ damage?

One of the most serious side effects of EDTA is kidney damage and kidney failure. Other side effects that have been reported in patients taking some forms of EDTA have included: Anemia. Chills, fever, or headache.

What is edetic acid?

More… Edetic Acid is the acid form of edetate, a chelating agent with anti-hypercalcemic and anticoagulant properties. Edetic acid binds calcium and heavy metal ions, forming soluble stable complexes which are readily excreted by the kidneys.

What are the different salts of EDTA?

A number of salts of EDTA are available with uses identical or similar to the acid. The USP salts are called edetates ( calcium disodium, disodium edetates); others are usually abbreviated to EDTA ( tetrasodium, trisodium EDTA ).

What is the EDTA limit for disodium salt?

Ethylenediaminetetraacetic acid (EDTA), disodium salt is included on this list. Limit: When ready for use, the end-use concentration is not to exceed 1400 ppm. 40 CFR 180.940 (b) (USEPA); U.S. National Archives and Records Administration’s Electronic Code of Federal Regulations.

What is the FDA public health advisory for edetate disodium?

On January 16, 2008, FDA issued a public health advisory to alert patients and healthcare professionals about important safety information concerning the drug edetate disodium (see ”FDA Public Health Advisory: Edetate Disodium (Marketed as ENDRATE and Generic Products),