CD34 is predominantly regarded as a marker of hematopoietic stem cells (HSC) and hematopoietic progenitor cells. However, CD34 is now also established as a marker of several other nonhematopoietic cell types, including vascular endothelial progenitors 1 and embryonic fibroblasts 2.

What is CD34 a marker for?

CD34 is predominantly regarded as a marker of hematopoietic stem cells (HSC) and hematopoietic progenitor cells. However, CD34 is now also established as a marker of several other nonhematopoietic cell types, including vascular endothelial progenitors 1 and embryonic fibroblasts 2.

What is CD31 and CD34?

CD34 is one of the Endothelial Cell Differentiation Markers and Endothelial Progenitor Cell Markers. CD31 is normally found on endothelial cells, platelets, macrophages and Kupffer cells, granulocytes, T / NK cells, lymphocytes, megakaryocytes, osteoclasts, neutrophils.

Where is CD34 expressed?

CD34 is a transmembrane glycoprotein expressed on early lymphohematopoietic stem cells, progenitor cells, and endothelial cells. Also, embryonic fibroblasts and some cells in fetal and adult nervous tissue are CD34-positive.

Why is CD34 important?

CD34 is a membrane protein that aids cells in cell-cell adhesion. Although little is known about its function, CD34 is an important marker for hematopoietic stem cells (HSCs), muscle satellite cells, and endothelial cells.

What is CD15 a marker for?

The glycan determinant CD15 (also known as Lewis x, or Le(x)) is a distinguishing marker for human myeloid cells and mediates neutrophil adhesion to dendritic cells.

What are CD31 positive cells?

CD31, also known as platelet endothelial cell adhesion molecule 1 (PECAM-1), is thought to be a sensitive and specific marker for vascular differentiation. It is a transmembrane glycoprotein expressed by endothelial cells and a variety of hematopoietic cells.

What is CD117 a marker for?

c-kit (also called CD117) is a type III receptor tyrosine kinase expressed predominantly in bone marrow stem/progenitor cells118 and has recently been identified as a marker for EPC and cardiac progenitor cell identity.

What does CD117 positive mean?

When a tumor biopsy tests positive for the biomarker CD117, the diagnosis is narrowed to two potential conclusions: renal oncocytoma, a benign kidney tumor that is not dangerous, and chromophobe renal cell carcinoma, a form of kidney cancer.

What cells are CD15 positive?

CD15 is a haemopoietic differentiation antigen expressed on most terminally differentiated myeloid cells including granulocytes, eosinophils, mast cells, monocytes/macrophages, and Langerhans’ cells. It is not expressed in red cells, platelets and lymphocytes (2).

What does CD34 negative mean?

A negative CD34 may exclude Ewing’s sarcoma/PNET, myofibrosarcoma of the breast, and inflammatory myofibroblastic tumors of the stomach. Injection of CD34+ hematopoietic stem cells has been clinically applied to treat various diseases including spinal cord injury, liver cirrhosis and peripheral vascular disease.

What is the difference between VE-cadherin and CD34+ HUVEC?

Immunofluorescence microscopy showed a small fraction of CD34+cells, whereas the vascular endothelial cell marker VE-cadherin was readily detectable in every cell (Fig. 2b). In the fraction of HUVEC cells that expressed CD34, CD34 staining was detected on all cell membrane domains, but these CD34+HUVEC cells had a distinct morphological appearance.

What do CD34+ cells mean?

In many cases, the CD34+cells represent a small proportion of the total cell population and also indicate a distinct subset of cells with enhanced progenitor activity. Herein, we explore common traits between cells that express CD34, including associated markers, morphology and differentiation potential.

Are CD34+HUVECs similar to tip cells in vivo?

These observations are in agreement with earlier reports describing that CD34+HUVECs have morphological characteristics similar to tip cells in vivo,which have filopodia at the leading front of the cells [7]. Open in a separate window Fig. 2

Is CD34 a marker of hematopoietic cells in MSC 58-60?

This is due to the consideration that CD34 is a marker of hematopoietic cells, alongside a number of previous studies that show an absence of CD34 in cultured MSC 58–60.