Caseation (caseum = cheese) is the “solid” necrosis of the exudative initial alveolar lesion and of the lung tissue surrounding the lesion. It results in alveolar destruction, but the elastic fibers of the alveolar walls and their vessels often persist within the caseous lesion.

What is Caseation necrosis?

Caseation (caseum = cheese) is the “solid” necrosis of the exudative initial alveolar lesion and of the lung tissue surrounding the lesion. It results in alveolar destruction, but the elastic fibers of the alveolar walls and their vessels often persist within the caseous lesion.

What is an example of caseous necrosis?

n. A type of tissue death in which all cellular outline is lost and tissue appears crumbly and cheeselike, usually seen in tuberculosis.

What are the features of caseous necrosis?

Caseous necrosis or caseous degeneration (/ˈkeɪsiəs/) is a unique form of cell death in which the tissue maintains a cheese-like appearance. It is also a distinctive form of coagulative necrosis. The dead tissue appears as a soft and white proteinaceous dead cell mass.

What is granuloma caseous necrosis?

Caseating granuloma means necrosis involving dead cells with no nuclei and debris. Without microscope, the cheese like pattern was seen in the these granulomas . In all reports of the CREMO patients, the granulomas were noncaseating .

Which of the following necrosis is seen in tuberculosis?

Tuberculosis: Central caseous necrosis may occur in tuberculosis and histoplasmosis; however, multinucleated Langhans giant cells characteristic of tuberculosis are not common in histoplasmosis.

What are types of necrosis?

There are many types of morphological patterns that necrosis can present itself. These are coagulative, liquefactive, caseous, gangrenous which can be dry or wet, fat and fibrinoid. Necrosis can start from a process called “oncosis”. Oncosis comes from the Greek origin ónkos, meaning swelling.

Is coagulative necrosis reversible?

Like most types of necrosis, if enough viable cells are present around the affected area, regeneration will usually occur.

Where is liquefactive necrosis most often seen?

In organs or tissues outside the CNS, liquefactive necrosis is most commonly encountered as part of pyogenic (pus-forming) bacterial infection with suppurative (neutrophil-rich) inflammation (see also Chapter 3) and is observed at the centers of abscesses or other collections of neutrophils.

What are caseous lesions?

Caseous lesions consist of necrotic cellular debris surrounded by a zone of suppurative inflammation. Depending on the duration of the lesions, they may be partially encapsulated by fibrous tissue.

What causes Caseating granuloma?

Caseating granulomas are formed by infections, such as tuberculosis and fungal infections. Noncaseating granulomas may be formed by an inflammatory condition (e.g., sarcoidosis and Crohn disease), vasculitis, and exposure to foreign objects. Formation of granulomas is characteristic of certain diseases.

How can you tell the difference between Caseating and Noncaseating granulomas?

Caseating granulomas have a central region of necrosis and classically appear “cheese-like” upon biopsy. These typically form in the lungs in response to tuberculosis and fungal infections. On the other hand, noncaseating granulomas do not have a central region of necrosis and occur more commonly.