(1) Endometrial hyperplasia with atypia is the least common type of hyperplasia, but is the type most likely to progress to type 1 endometrial carcinoma (1-3) which accounts for 97% of uterine cancers, whereas simple hyperplasia rarely progresses to carcinoma.

Is endometrial hyperplasia with atypia cancer?

(1) Endometrial hyperplasia with atypia is the least common type of hyperplasia, but is the type most likely to progress to type 1 endometrial carcinoma (1-3) which accounts for 97% of uterine cancers, whereas simple hyperplasia rarely progresses to carcinoma.

Can endometrial hyperplasia with atypia be cured?

This condition may improve without treatment. Hormone therapy helps in some cases. Simple or complex atypical endometrial hyperplasia: An overgrowth of abnormal cells causes this precancerous condition. Without treatment, your risk of endometrial or uterine cancer increases.

How common is endometrial hyperplasia with atypia?

The incidence rates of the endometrial hyperplasia subtypes are 121 per 100,000 woman-years for non-atypical hyperplasia and 16.8 per 100,000 woman-years for atypical hyperplasia [3, 13]. Abnormal uterine bleeding is the most common presenting symptom of endometrial abnormalities, hyperplasia, or cancer.

How fast does endometrial hyperplasia turn into cancer?

In one study, hyperplasia without atypia progressed to endometrial carcinoma in fewer than 5% of women; in comparison, atypical hyperplasia progressed to endometrial carcinoma in one in eight women within 10 years, and in one in three women within 20 years.

Can a thick uterine lining cause weight gain?

Endometriosis causes endometrial tissue, which usually lines the uterus, to develop outside of the uterus. It can cause chronic pain, heavy or irregular periods, and infertility. Some people also report weight gain and bloating.

What does hyperplasia with atypia mean?

Atypical hyperplasia (or atypia) means that there are abnormal cells in breast tissue taken during a biopsy. (A biopsy means that tissue was removed from the body for examination in a laboratory.) These abnormal cell collections are benign (not cancer), but are high-risk for cancer.

Does endometrial hyperplasia cause weight gain?

It can cause chronic pain, heavy or irregular periods, and infertility. Some people also report weight gain and bloating.

What is cytologic atypia?

Cytologic atypia is defined by the presence of nuclei that are large, regularly shaped and hyperchromic, at times showing binucleation and dyskeratosis and presenting with absence of a perinuclear halo. Cytologic atypia can also be found in metaplastic cells.