Thyroglobulin (Tg) is a 660 kDa, dimeric glycoprotein produced by the follicular cells of the thyroid and used entirely within the thyroid gland.

What is Thyreoglobulin AK?

Thyroglobulin (Tg) is a 660 kDa, dimeric glycoprotein produced by the follicular cells of the thyroid and used entirely within the thyroid gland.

What does it mean if thyroglobulin is high?

Very high levels of thyroglobulin may suggest metastatic or recurrent disease. About one-fourth of patients who have thyroid cancer have antibodies to thyroglobulin. Antibodies should be checked along with thyroglobulin because if they are present, they could interfere with measurement of thyroglobulin.

What is the normal thyroglobulin range?

The normal range for thyroglobulin is: 1.40 – 29.2 ng/mL (μg/L) for men. 1.50 – 38.5 ng/mL for women.

What is considered a high level of thyroglobulin antibodies?

In a healthy individual, Thyroglobulin Antibodies need to be less than 20 IU/mL. When levels are higher than 20, this usually indicates a high level of antibodies, which means that the body’s immune system is attacking the thyroid gland.

What should thyroglobulin be after total thyroidectomy?

The interpretation of serum Tg depends on the type of initial therapy. For patients with total thyroidectomy and radioiodine remnant ablation, non-stimulated Tg should be <0.2 ng/mL and stimulated Tg <1 ng/mL in the absence of interfering antibodies.

What is a normal thyroglobulin tumor marker after thyroidectomy?

The authors showed that a thyroglobulin level > 50 ng/dl after initial surgery and without thyroid hormone replacement is able to accurately predict future reappearance of thyroid cancer in 97% of high risk patients, while an undetectable thryoglobulin level was a good predictor of an excellent outcome from thyroid …

What are thyroid antibodies symptoms?

It occurs when your body makes antibodies that attack the cells in your thyroid. Symptoms may include an enlarged thyroid gland (goiter), tiredness, weight gain, and muscle weakness. You don’t need treatment if your thyroid hormone levels are normal. If you have an underactive thyroid, medicine can help.

What causes increase in thyroglobulin?

Certain factors, such as gene defects, virus infection, iodine intake, stress or destruction of thyroid follicles caused by thyroid nodules (such as patients in high Tg group in the present study) and cancer, can lead to a raise of Tg level (30, 41, 42).

What happens if thyroid antibodies are high?

In general, the presence of thyroid antibodies suggests the presence of an autoimmune thyroid disorder and the higher the level, the more likely that is. Levels of autoantibody that rise over time may be more significant than stable levels as they may indicate an increase in autoimmune disease activity.

What are the symptoms of high thyroglobulin antibodies?

If you have an underlying thyroid condition, high thyroglobulin antibodies may be associated with the symptoms of that condition.

  • Face and eye swelling.
  • Fragile hair.
  • Voice changes.

Was sind die Antikörper gegen Thyreoglobulin?

Tg-AK sind Antikörper gegen Thyreoglobulin. Thyreoglobulin ist ein von den Schilddrüsenzellen hergestelltes Protein. In der Schilddrüsenzelle ist es für die Produktion und Speicherung von Schilddrüsenhormonen verantwortlich. Bei der autoimmunen Schilddrüsenerkrankung vom Typ Basedow können ebenfalls gelegentlich Tg-AK nachgewiesen werden.

Was ist das Thyreoglobulin?

Das Thyreoglobulin ist ein Protein, das ausschließlich in der Schilddrüse als Vorläufer für Thyroxin und Trijodthyronin gebildet wird.Thyreoglobulin-Antikörper treten auf bei destruierenden Prozessen (z. B. Thyreoiditis, Schilddrüsenneoplasie) Postpartale Thyreoiditis – Sonderform der chronischen Thyreoiditis, die nach einer Entbindung auftritt.

Was ist das Glykoprotein Thyreoglobulin?

Das Glykoprotein Thyreoglobulin ( Molekulargewicht ca. 660.000 Dalton) liegt in Form langer Ketten mit jeweils etwa 130 Tyrosin -, T1 -, T2 -, T3 – und T4 -Resten vor. Es hat einen Kohlenhydratanteil von ca. 10% und besteht aus zwei Untereinheiten mit einem Molekulargewicht von jeweils etwa 330.000 Dalton, die über Disulfidbrücken verbunden sind.

Kann ein erhöhter Thyreoglobulin-Wert Krebs verursachen?

Ein erhöhter Thyreoglobulin-Wert kann auf Schilddrüsenkrebs hinweisen (follikuläres Karzinom, papilläres Karzinom). Aber auch bei gutartigen Erkrankungen der Schilddrüse kann der Thyreoglobulin-Spiegel im Blut erhöht sein.