Concerning CK7 and CK20, the number of positive cells in the array was recorded as a percent. For CK7, staining in > 10% of tumor cells was considered a positive sample. For CK20, staining in > 25% of tumor cells was considered positive (Fig. 1).

What is CK7 positive & CK20 positive mean?

Concerning CK7 and CK20, the number of positive cells in the array was recorded as a percent. For CK7, staining in > 10% of tumor cells was considered a positive sample. For CK20, staining in > 25% of tumor cells was considered positive (Fig. 1).

What does a positive CK7 mean?

Positive for CK7 means that immunohistochemistry was performed and CK7 protein was seen inside the cells of interest in the tissue sample. Reactive is another term that pathologists use to describe cells that are producing CK7.

What tumors are CK7 positive?

For example, a CK7-negative/CK20-positive phenotype is often associated with carcinomas of colorectal origin, whereas a CK7-positive/CK20-negative phenotype is seen in a wide variety of carcinomas, including carcinomas of the lung, breast, thyroid, pancreas, and female genital tract.

What is CK7 and CK20?

CK7 is found in the glandular epithelium and epithelial tumors of lung, ovary, endometrium and breast, but is not found in GI epithelium. Conversely, CK20 is expressed principally in the normal glands and epithelial tumors of the GI tract, urothelium, and Merkel cells.

What are CK7 cells?

Cytokeratin 7 (CK7) is specifically expressed in the simple epithelia lining the cavities of internal organs and in transitional epithelium. Epithelial cells of the lung and breast can express CK7, but glandular epithelia of the colon and prostate do not express CK7 10.

Is CK7 positive in squamous cell carcinoma?

Interestingly, most squamous cell carcinomas, in general, are negative for both CK7 and CK20, with the exception of cervical squamous cell carcinomas, which are frequently positive for CK7.

What is CK7 in pathology?

What does CK7 stain for?

CK7 will variably stain the majority of cells in biliary and gastric tumors. 3. Carcinomas that are almost invariably negative but may occasionally show rare CK7-positive cells include hepatomas, duodenal ampulla carcinomas, colon carcinomas, and adrenal cortical tumors.

Is CK7 positive in mesothelioma?

Furthermore, CK7 negativity most often is associated with metastases, and the CK20+/7- pattern, typical of colorectal adenocarcinomas, is absent in pleural mesotheliomas.

What is CK7 marker?

Cytokeratin 7 (CK7) is a type II basic low molecular weight cytokeratin that is found in simple epithelia in a variety of organs, including all epithelia in the female genital tract. 305,306. Epithelial tumors of the ovary and fallopian tube all exhibit cytoplasmic and/or membrane staining for CK7.

Which adenocarcinomas have both CK7 and CK20 expression?

One of the adenocarcinomas that has been reported to be positive for both CK7 and CK20 expression is mucinous bronchioloalveolar adenocarcinoma of the lung. Goldstein and Thomas (2001)evaluated the expression of CK7 and CK20 in 14 cases of mucinous bronchioloalveolar adenocarcinomas (BAC) and 11 cases of mucinous colon adenocarcinomas.

Should CK20 and CK7 be included in the differential diagnoses of mesothelioma?

The CK20+/7- pattern was typical for gastrointestinal tumors. Conclusions: Adding CK20 and CK7 to the panel of antibodies in the differential diagnosis of pleural mesothelioma versus metastatic adenocarcinomas is useful because diffuse CK20 positivity seems to be an indicator of metastasis.

How many primary colon lesions are CK7-/CK20+?

All the primary colon lesions (26) were CK7−/CK20+ (Figure 2). Open in a separate window Figure 1 CK20 (A) and CK7 (B) immunostaining of primary lung adenocarcinoma. CK20 (C) and CK7 (D) immunostain of metastatic lung adenocarcinoma to the liver.

Does staining for both CK7 and CK20 exist?

Staining for both CK7 and CK20 has been reported in the literature for some tumours (Loy and Calaluce, 1994). One of the adenocarcinomas that has been reported to be positive for both CK7 and CK20 expression is mucinous bronchioloalveolar adenocarcinoma of the lung.