Ovariectomized rats were used in this experiment to ensure control over the hormones in the rats. Without the ovaries, the rats were not able to produce estrogen, and therefore had low baseline T scores already, since estrogen stimulates bone growth and protects against osteoprosis.

Why are ovariectomized rats used?

Ovariectomized rats were used in this experiment to ensure control over the hormones in the rats. Without the ovaries, the rats were not able to produce estrogen, and therefore had low baseline T scores already, since estrogen stimulates bone growth and protects against osteoprosis.

Why are mice ovariectomized?

When rats and mice are used in estrogen research they are commonly ovariectomized in order to ablate the rapidly cycling hormone production, replacing the 17β-estradiol exogenously. There is, however, lack of consensus regarding how the hormone should be administered to obtain physiological serum concentrations.

Do rats get osteoporosis?

Osteoporosis in rats is verified by lower bone mineral density and lower trabecular number and thickness as well as higher trabecular separation, changes that are observed at 14, 30, and 60 days post-OVX in proximal tibia, lumbar vertebrae and femur, respectively.

What are the risks of hormone replacement therapy?

Research has shown that MHT is associated with the following health effects:

  • Hip and vertebral fractures.
  • Vaginal bleeding.
  • Urinary incontinence.
  • Dementia.
  • Stroke, blood clots, and heart attack.
  • Breast cancer.
  • Lung cancer.
  • Colorectal cancer.

Is ovariectomy a word?

noun, plural o·var·i·ec·to·mies. Surgery. the operation of removing one or both ovaries; oophorectomy.

What are OVX mice?

An ovariectomized rat (OVX) is a female rat whose ovaries have been removed. Currently there is no single animal model that identically represents the stages of osteoporosis in humans although there are some animals that are relatively close and can be used for the purpose of comparison.

What type of skeleton does a rat have?

Rats have a skeleton made of bones connected with joints and cartilage, just like we do.

What are signs of high testosterone in females?

Symptoms of too much testosterone in women

  • excess body hair, specifically facial hair.
  • balding.
  • acne.
  • enlarged clitoris.
  • decreased breast size.
  • deepening of the voice.
  • increased muscle mass.