Tramadol is in a class of medications called opiate (narcotic) analgesics. It works by changing the way the brain and nervous system respond to pain.

What is the pharmacological class of tramadol?

Tramadol is in a class of medications called opiate (narcotic) analgesics. It works by changing the way the brain and nervous system respond to pain.

What is the pharmacokinetics of tramadol?

Tramadol is extensively metabolized in the liver by O – and N-demethylation and by conjugation reactions to form glucuronides and sulfates. Elimination of Tramadol and its metabolites is predominantly via the kidneys.

Is tramadol A SNRI?

Tramadol is also a serotonin–norepinephrine reuptake inhibitor (SNRI).

Can tramadol be given intravenously?

Tramadol hydrochloride solution for injection or infusion may be administered intramuscularly, by slow intravenous injection, or diluted in solution (see Section 6.6) for administration by infusion or patient controlled analgesia. Intravenous injections must be given slowly over 2-3 minutes.

What is the indication of tramadol?

It has specific indications for moderate to severe pain. It is considered a class IV drug by the FDA and has been since July of 2014. Due to possible misuse disorder potential, limitations to its use should be for pain that is refractory to other pain medication, such as non-opioid pain medication.

Is tramadol given IV or IM?

Is tramadol structurally an opioid?

A unique analgesic, tramadol is an atypical opioid, a 4-phenyl-piperidine analogue of codeine, with partial mu agonist activity in addition to central GABA, catecholamine and serotonergic activities.

Can you give tramadol with an SSRI?

The combination of tramadol and SSRIs or SNRIs can result in the serotonin syndrome, which is potentially dangerous but easily avoidable if prescribers are aware of this risk.

Can you take tramadol with a SSRI?

Objectives: The combination of a selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine reuptake inhibitor (SNRI) with tramadol can result in serotonin syndrome, characterised by neuromuscular and autonomic nervous system excitation and altered mental state.

Does tramadol stop urine flow?

Tramadol is an opioid agonist, however, and morphine is known to increase the tonus of the bladder sphincter and to cause urinary retention.