What is GSTM1 null?
Glutathione S-transferases M1 (GSTM1) is an important phase II metabolizing enzyme. The null genotype of GSTM1 causes total loss of GSTM1 enzyme activity and numerous studies have investigated the association between GSTM1 null genotype and gastric cancer risk.
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What is GSTM1 null?
Glutathione S-transferases M1 (GSTM1) is an important phase II metabolizing enzyme. The null genotype of GSTM1 causes total loss of GSTM1 enzyme activity and numerous studies have investigated the association between GSTM1 null genotype and gastric cancer risk.
What does GSTM1 do?
GSTM1 is a glutathione S-transferase (GST) which play a role in the detoxification of metabolites of environmental carcinogens including tobacco smoke. There is some evidence to suggest that people with common polymorphisms of these genes may have an increased susceptibility to a range of different cancers.
What is GSTT1 gene?
Glutathione S-transferase theta-1 is an enzyme that in humans is encoded by the GSTT1 gene. Glutathione S-transferase (GST) theta 1 (GSTT1) is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds.
What is null genotype?
A null allele is a nonfunctional allele (a variant of a gene) caused by a genetic mutation. Such mutations can cause a complete lack of production of the associated gene product or a product that does not function properly; in either case, the allele may be considered nonfunctional.
What is neomorphic mutation?
Definition. A type of mutation in which the altered gene product possesses a novel molecular function or a novel pattern of gene expression. Neomorphic mutations are usually dominant or semidominant.
What is a leaky allele?
They make an incompletely functioning product. This could occur via reduced transcription or via the production of a product that lacks complete activity. These alleles are sometimes referred to as Leaky mutations, because they provide some function, but not complete function.
What causes a neomorphic mutation?
A neomorphic mutation causes a dominant gain of gene function that is different from the normal function. A neomorphic mutation can cause ectopic mRNA or protein expression, or new protein functions from altered protein structure. Changing wildtype gene dose has no effect on the phenotype of a neomorph.
What is the meaning of neomorphic?
From Wikipedia, the free encyclopedia. Neomorphism refers to the wet metamorphic process in which diagenetic alterations systematically transform minerals into either polymorphs or crystalline structures that are structurally identical to the rock(s) from which they developed.
What are Hypomorphs?
Medical Definition of hypomorph : a mutant gene having a similar but weaker effect than the corresponding wild-type gene.
What are leaky mutants?
A mutant (typically an auxotroph) that results from a partial rather than a complete inactivation of the wild-type function.
What is a neomorphic mutation?
Definition. A type of mutation in which the altered gene product possesses a novel molecular function or a novel pattern of gene expression. Neomorphic mutations are usually dominant or semidominant. See also: Amorphic Mutation.
What causes a Neomorph?
Neomorph alleles produce an active product with a new, different function, something that the wild type allele doesn’t do. It can be either new expression (new tissue or time) or a mutation in the product to create a new function (additional substrate or new binding site), not present in the wild type product.
What is the function of GSTM1?
GSTM1 is a glutathione S-transferase (GST) which play a role in the detoxification of metabolites of environmental carcinogens including tobacco smoke. There is some evidence to suggest that people with common polymorphisms of these genes may have an increased susceptibility to a range of different cancers.
How do you calculate specific enzyme activity?
Finally, the specific activity amount was calculated using the Total units of enzyme activity calculated in procedure 2 divided by the average total protein calculated in procedure 1. Total Units of Enzyme Activity Total Protein 0.672 = 0.344 Units/mg. 1.956. 0.78 = 0.400 Units/mg.
Is there a relationship between GSTM1 and cancer?
Latest Publications: GSTM1 (cancer-related) When considered together, GSTM1 and GSTT1 genotypes were found to be associated with an increased risk of breast cancer. The relationship between GSTM1 and GSTT1 gene deletions and breast cancer risk was substantially altered by consumption of Smoked Meat/Vegetable.
What is the effect of the GSTM1 null allele on lung cancer?
Other research (Bennett, 1999) indicates that people with the GSTM1 null allele may be more suseptible to lung cancer on exposure to envoronmental tabacco smoke. Several studies have indicated significantly increased susceptibility to acuate leukemia, including childhood ALL, with a GSTM1 null genotype and also associated with GSTT1 polymorphisms.
