Is Cystic Fibrosis an example of pleiotropy?

The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene is expressed in many different tissues and has many phenotypic effects. In other words, it is a pleiotropic gene.

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The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene is expressed in many different tissues and has many phenotypic effects. In other words, it is a pleiotropic gene.

Is sickle cell pleiotropy?

The sickle cell gene is pleiotropic in nature. Although it is a single gene mutation, it has multiple phenotypic expressions that constitute the complications of sickle cell disease.

What is pleiotropic disease?

Pleiotropy refers to disorders where multiple, seemingly unrelated organ systems are affected. For example, one individual in a pedigree may exhibit cardiac arrhythmia, whereas another individual with the same disorder in either the same or different pedigree shows muscle weakness and deafness.

Is albinism a pleiotropy?

Pleiotropy is exhibited by all types of albinism; single gene mutations have effects on different organ systems. The most obvious systems involved are the integument and the eyes, but the nervous, haematological, respiratory, and gastrointestinal systems may occasionally be affected.

Is haemophilia example of pleiotropy?

No. Haemophilia A is not a pleiotropic gene. Haemoglobin S (HbS)is a pleiotropic gene. A pleiotropic gene refers to how a single gene controls several distinct and unrelated phenotypic effects.

What is the most common example of pleiotropy in human?

One of the most widely cited examples of pleiotropy in humans is phenylketonuria (PKU). This disorder is caused by a deficiency of the enzyme phenylalanine hydroxylase, which is necessary to convert the essential amino acid phenylalanine to tyrosine.

What is meant by Pleiotropism give two examples?

Pleiotropism is the condition in which a single gene controls more than one phenotypic effect, that is completely unrelated. E.g.: Phenylketonuria. It is an autosomal recessive disorder affecting chromosome number 12.

Is height a pleiotropy?

Height and other similar features are controlled not just by one gene, but rather, by multiple (often many) genes that each make a small contribution to the overall outcome. This inheritance pattern is sometimes called polygenic inheritance (poly- = many).

What is pleiotropy Toppr?

Pleiotrophy. Pleiotropy occurs when one gene influences two or more seemingly unrelated phenotypic traits.

What is pleiotropy typically?

Pleiotropy is the expression of multiple traits by a single gene. Typically, traits are determined by two alleles (variant form of a gene). Specific allele combinations determine the production of proteins which drive the processes for the development of phenotypic traits. A mutation occurring in a gene alters the DNA sequence of the gene.

Is sickle cell anemia an example of pleiotropy?

Pleiotropy occurs when one gene will code and control the phenotype or expression of several different and unrelated traits. For example, phenylketonuria is a disease caused by pleiotropy. Sickle cell anemia is also a disease caused by pleiotropy.

Which of the following illustrates pleiotropy?

Which of the following illustrates pleiotropy? In fruit flies, the genes for scarlet eyes and hairy body are located on the same chromosome. Matings between earless sheep and long-eared sheep always result in short-eared offspring. Wheat kernels can range from white to red in color, a trait controlled by several genes.