Paracetamol has a central analgesic effect that is mediated through activation of descending serotonergic pathways. Debate exists about its primary site of action, which may be inhibition of prostaglandin (PG) synthesis or through an active metabolite influencing cannabinoid receptors.

What is the mechanism of action of paracetamol?

Paracetamol has a central analgesic effect that is mediated through activation of descending serotonergic pathways. Debate exists about its primary site of action, which may be inhibition of prostaglandin (PG) synthesis or through an active metabolite influencing cannabinoid receptors.

What is the mechanism of paracetamol in controlling fever?

Paracetamol reduces fever by affecting an area of the brain that regulates our body temperature (the hypothalamic heat-regulating center). Paracetamol is about as effective as aspirin and ibuprofen at relieving mild to moderate pain and reducing fever, but unlike these it doesn’t reduce inflammation.

What is the generic name of acetaminophen?

Yes. Acetaminophen (Tylenol) is the brand name and acetaminophen is the generic name. They both work the same.

What is the classification of paracetamol?

DESCRIPTION. Acetaminophen (IUPAC: N(4-hydroxyphenyl)acetamide, chemical formula: C8H9NO2), also known as paracetamol, is classified as an “Aniline analgesic” and it is the only drug of this family still used nowadays.

What is mechanism action?

(MEH-kuh-nih-zum … AK-shun) In medicine, a term used to describe how a drug or other substance produces an effect in the body. For example, a drug’s mechanism of action could be how it affects a specific target in a cell, such as an enzyme, or a cell function, such as cell growth.

What is the pharmacodynamics of paracetamol?

Pharmacodynamics/Mechanism of action: Paracetamol is a p-aminophenol derivative that exhibits analgesic and antipyretic activity. It does not possess anti-inflammatory activity. Paracetamol is thought to produce analgesia through a central inhibition of prostaglandin synthesis.

Is paracetamol an agonist or antagonist?

CB(1) receptor antagonist, at a dose level that completely prevents the analgesic activity of a selective CB(1) receptor agonist, completely prevents the analgesic activity of paracetamol. Thus, paracetamol acts as a pro-drug, the active one being a cannabinoid.

What is generic name?

n. The official nonproprietary name of a drug, under which it is licensed and identified by the manufacturer. The first name of the two-part Latin taxonomic name of an organism, which specifies the biological genus.

What are the three fundamental mechanisms of drug action?

A number of mechanisms exist for the passage of drugs across the plasma membrane, including passive diffusion, facilitated diffusion, and active transport systems.

What is pharmacokinetics and pharmacodynamics?

In simple words, pharmacokinetics is ‘what the body does to the drug’. Pharmacodynamics describes the intensity of a drug effect in relation to its concentration in a body fluid, usually at the site of drug action. It can be simplified to ‘what the drug does to the body’.