GLI1 (GLI Family Zinc Finger 1) is a Protein Coding gene. Diseases associated with GLI1 include Polydactyly, Postaxial, Type A8 and Polydactyly, Preaxial I.

What is GLI zinc finger family?

GLI1 (GLI Family Zinc Finger 1) is a Protein Coding gene. Diseases associated with GLI1 include Polydactyly, Postaxial, Type A8 and Polydactyly, Preaxial I.

What is gene family expansion?

The expansion of a gene cluster is the duplication of genes that leads to larger gene families.

Are zinc finger transcription factors?

Zinc finger proteins are the largest transcription factor family in human genome. The diverse combinations and functions of zinc finger motifs make zinc finger proteins versatile in biological processes, including development, differentiation, metabolism and autophagy.

How do zinc fingers interact with DNA?

The binding of zinc finger is found to be distinct from many other DNA-binding proteins that bind DNA through the 2-fold symmetry of the double helix, instead zinc fingers are linked linearly in tandem to bind nucleic acid sequences of varying lengths. Zinc fingers often bind to a sequence of DNA known as the GC box.

What is GLI family?

Gli family The GLI1, GLI2, and GLI3 genes encode transcription factors which all contain conserved tandem C2-H2 zinc finger domains and a consensus histidine/cysteine linker sequence between zinc fingers. This Gli motif is related to those of Kruppel which is a Drosophila segmentation gene of the gap class.

What generates a gene family?

Gene families are usually created by consecutive gene duplication events. The main molecular mechanism that results in gene duplication is unequal crossing over between misaligned sequences.

What is the largest gene family?

The olfactory receptor (OR) genes constitute the largest gene family in mammalian genomes. Humans have >1,000 OR genes, of which only ∼40% have an intact coding region and are therefore putatively functional.

Is zinc finger a secondary structure?

The “finger” refers to the secondary structures (α-helix and β-sheet) that are held together by the Zn ion. Zinc finger containing domains typically serve as interactors, binding DNA, RNA, proteins or small molecules (Laity et al., 2001).

What is the function of a zinc finger?

Abstract. Zinc finger proteins are among the most abundant proteins in eukaryotic genomes. Their functions are extraordinarily diverse and include DNA recognition, RNA packaging, transcriptional activation, regulation of apoptosis, protein folding and assembly, and lipid binding.